In ancient Greece and found that men who had been castrated (eunuch) They had a wonderful hair,compared with men aged between 30 y 50 años, they had already lost much of her hair.
Subsequent research has established the relationship between a type of baldness, today called androgenic alopecia,and testosterone(hormone secreted mainly in the testis).
This type of baldness occurs when testosterone is converted to dihydrotestosterone (DHT), due to the presence of the enzyme 5-reductase type II,
Today we know that there are two types of enzyme 5 alpha reductase, type I and type II, which produce two genes located on different chromosomes and have different structures. Type I is found all over the skin, and the second is mainly in the skin of the genitals (prostate).
Thus we say that this type of alopecia has a genetic origin.
Androgenic alopecia in the growth phase of hair follicles is shortened.
Hair decrease in size and thickness, born increasingly fewer and finer,to become hair.
In some adults it causes hair follicles to shrink.
We might think that more testosterone biggest problem with hair,but actually it is not testosterone itself responsible.
The culprit is an enzyme,5-alpha reductase type II that acts as follows:
When testosterone reaches the person's hair with a tendency to baldness, this typically contains more enzymes(5-alpha reductase type II), facilitating conversion of testosterone to DHT (dihidrotestosterona),
In men who do not have this enzyme or have sparingly,this transformation occurs not.
Testosterone reaching the hair follicle,continues as testosterone. No transformation into DHT
This conversion of testosterone to DHT is the cause of androgenetic baldness.
What can we do?
The solution for this type of baldness can be blocking the enzyme 5-alpha reductase type II.
Enzyme inhibitors 5-alpha reductase type II.
Many of the inventions in history happen almost by chance.
That same thing happened with a drug,originally formulated to treat problems of abnormal prostate enlargement (HPB).
It was noted that many of the individuals who had been treated with this new drug,They exhibited an increase in capillary density in certain areas of the head, and even recovered hair in areas where there were hardly any.
From that moment the drug began to be considered as a possible solution to male pattern baldness androgenetic.
The drug acts by inhibiting the enzyme 5-alpha reductase type II, as we have already discussed, It is the main responsible for this type of baldness.
The problem is that after several years of being used,described side effects,
severe depression and impotence are some of the side effects attributed.
In the plant world we can find solutions, without the undesirable side effects of the drug.
These plants is set forth below inhibit the 5-alpha reductase type II and can be used both in the treatment of benign prostatic hyperplasia as in the treatment of androgenic alopecia.
So? Is the only thing androgenic alopecia is male?
We may think that this type of alopecia seems a small problem or unlikely among women, but the reality is that it is a disorder that affects many women and especially in periods where hormonal changes like menopause or pregnancy.
So women can also suffer from androgenetic alopecia or female (MAKE) .